General Information

  • ID:  hor000686
  • Uniprot ID:  Q99JA0(83-119)
  • Protein name:  Calcitonin gene-related peptide 1
  • Gene name:  Calca
  • Organism:  Mus musculus (Mouse)
  • Family:  Calcitonin family
  • Source:  animal
  • Expression:  Detected in nerve cells of cerebrum, hippocampus and pons/midbrain in newborns, and only in nerve cells of pons/midbrain in adult.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Mus (subgenus), Mus (genus), Murinae (subfamily), Muridae (family), Muroidea, Myomorpha (suborder), Rodentia (order), Glires, Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005102 signaling receptor binding; GO:0005179 hormone activity; GO:0031716 calcitonin receptor binding; GO:0042802 identical protein binding; GO:0044877 protein-containing complex binding
  • GO BP:  GO:0001503 ossification; GO:0001976 nervous system process involved in regulation of systemic arterial blood pressure; GO:0001984 artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure; GO:0006874 intracellular calcium ion homeostasis; GO:0006939 smooth muscle contraction; GO:0006954 inflammatory response; GO:0007165 signal transduction; GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway; GO:0007218 neuropeptide signaling pathway; GO:0007631 feeding behavior; GO:0009408 response to heat; GO:0030279 negative regulation of ossification; GO:0042311 vasodilation; GO:0045776 negative regulation of blood pressure; GO:0045986 negative regulation of smooth muscle contraction; GO:0048240 sperm capacitation; GO:0048265 response to pain; GO:0050965 detection of temperature stimulus involved in sensory perception of pain; GO:0051480 regulation of cytosolic calcium ion concentration; GO:1990090 cellular response to nerve growth factor stimulus
  • GO CC:  GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005737 cytoplasm; GO:0030424 axon; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043195 terminal bouton; GO:0098686 hippocampal mossy fiber to CA3 synapse; GO:0098992 neuronal dense core vesicle

Sequence Information

  • Sequence:  SCNTATCVTHRLAGLLSRSGGVVKDNFVPTNVGSEAF
  • Length:  37(83-119)
  • Propeptide:  MGFLKFSPFLVVSILLLYQACSLQAVPLRSILESSPGMATLSEEEVRLLAALVQDYMQMKARELEQEEEQEAEGSSVTAQKRSCNTATCVTHRLAGLLSRSGGVVKDNFVPTNVGSEAFGRRRRDLQA
  • Signal peptide:  MGFLKFSPFLVVSILLLYQACSLQA
  • Modification:  T37 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  Calcr, Ramp1
  • Target Unid:  Q60755, Q9WTJ5
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: 9.00 (plasma half-life) minutes; /540 seconds ( PubMed ID: 1911217 )

Structure

  • Disulfide bond:  45695
  • Structure ID:  AF-Q99JA0-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor000686_AF2.pdbhor000686_ESM.pdb

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Physical Information

Mass: 445159 Formula: C162H263N49O53S2
Absent amino acids: IMQWY Common amino acids: V
pI: 8.24 Basic residues: 4
Polar residues: 17 Hydrophobic residues: 13
Hydrophobicity: 15.14 Boman Index: -4671
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 78.92
Instability Index: 3154.32 Extinction Coefficient cystines: 125
Absorbance 280nm: 3.47

Literature

  • PubMed ID:  11761712##1911217
  • Title:  Structure of the Mouse Calcitonin/Calcitonin Gene-Related Peptide Alpha and Beta Genes